This Cajun Crab Stuffed Salmon is made with tender, fresh salmon filled with a savory crab mixture seasoned with classic Cajun flavors. It’s baked into an elegant, yet comforting dinner, perfect for casual weeknight or special occasions.

❤️ Why You’ll Love This Stuffed Salmon Recipe

• Tender fresh salmon
• Stuffed with a sweet crab meat filling
• Seasoned with classic cajun flavors
• Baked to perfection
• Ideal for a special occasion dinner

My recipe for Cajun Crab Stuffed Salmon makes an easy yet impressive seafood dinner with a savory crab filling layered over fresh, buttery salmon. The mixture comes together in one bowl and spreads easily over each fillet. As it bakes, the salmon turns tender and flaky while the crab topping settles into a creamy, seasoned stuffing.

I especially love how just a touch of Cajun seasoning adds the perfect kick without overpowering the natural flavors of the seafood and brings the whole dish together. Serve it with your favorite side salad, over cauliflower rice, or with fresh vegetables for a comforting and healthy meal that works for both weeknights and special occasions.

If you love the flavors in this recipe, you should also try my Cajun Salmon Alfredo.

🛒 Ingredients for Crab Stuffed Salmon

• Salmon
• Crab meat
• Parmesan cheese
• Mayonnaise
• Garlic 
• Dijon mustard
• Lemon
• Cajun seasoning
• Chives
• Hot sauce
• Salt
• Ground black pepper

*Exact measurements are listed in the recipe card below.

🥣 Recommended Tools

• Mixing bowl
• Whisk
• Baking sheet with wire rack
• Meat thermometer

🔪 How to Make Cajun Crab Stuffed Salmon

Preheat oven to 375°F. 

In a mixing bowl, add all the ingredients except for the salmon and crab, and only half the salt.

Whisk until combined.

Then add in the crab meat and gently mix, just until combined, then set it aside.

Take each piece of salmon and cut a slit in the very center, but make sure not to cut all the way through to the bottom.

Brush the olive oil over the salmon and sprinkle with the remaining salt.

Place the salmon on a baking sheet lined with a wire rack and aluminum foil (for easier cleanup).

Spoon some of the crab filling over the salmon.

Bake for 15-17 minutes or until the salmon is cooked through and reaches an internal temperature of at least 120°F, when checked with a meat thermometer.

Serve with a squeeze of lemon over the tops.

☑️ Storage Instruction

Refrigerator: Store leftovers in an airtight container for up to 2 days.

Freezer: Freeze fully cooked salmon for up to 1 month, tightly wrapped to prevent freezer burn. Thaw overnight in the fridge before gentle reheating in the oven on 350 degrees.

🍴 What to Serve with Cajun Stuffed Salmon

Though the Cajun seasoning is loaded with flavor, it’s such a versatile dish and can be served with a simple green salad or most any vegetable side dish. If you’re looking for some great low carb inspiration, check out some of these side dishes:

• Spicy Bang Bang Cole Slaw
• Easy Creamed Spinach
• Grilled Bacon Wrapped Asparagus
• Green Beans Almondine
• Cheesy Mashed Cauliflower
• Cauliflower Rice

💡 Tips

• Buy salmon fillets that are thick enough to hold the filling without tearing.
• Keep the slit shallow so the filling sits on top instead of sinking inside.
• Drain the crab meat very well to prevent a watery filling.
• Mix the filling just until combined so the crab stays chunky.
• Bake on a wire rack to avoid steaming the bottom of the salmon.
• Pull the salmon as soon as it reaches 120°F to avoid drying it out.

🔄 Substitutions and Additions

• Celery: Add finely minced celery to the filling for a subtle crunch.

• Seasoning: Use Old Bay instead of Cajun seasoning for a milder flavor profile.

• Shrimp: Add chopped shrimp to the crab mixture for a seafood combo filling.

• Parsley: Swap chives for parsley if you want a brighter finish.

• Lemon: Add lemon slices to the baking tray for extra citrus aroma while baking.

• Butter: Finish with a light drizzle of melted butter before serving.

Can I Use Frozen Salmon for This Recipe?

Yes, just make sure it is fully thawed and patted very dry before stuffing so the filling stays creamy.

What Type of Salmon Works Best for Stuffing?

Center cut fillets are ideal because they are thicker and hold the crab filling without falling apart.

Can I Use Imitation Crab Instead of Real Crab Meat?

You can, but the flavor will be milder and slightly sweeter than real lump crab meat.

Is This Salmon Spicy?

The Cajun seasoning adds flavor, not a lot of heat. You can reduce the hot sauce if you want it spicier.

Can This Be Cooked in an Air Fryer Instead of the Oven?

Yes. Cook at 375°F and start checking for doneness around 10 to 12 minutes.

🍽️ More Salmon Recipes

• Bang Bang Salmon Cakes
• Spinach Artichoke Stuffed Salmon
• Baked Salmon with Creamy Dill Sauce
• Smoked Salmon Cucumber Bites
• Asian Glazed Salmon
• Cajun Salmon Alfredo
• Easy Salmon Piccata with Spinach