Keto Chicken Florentine Casserole

Tender chicken, sautéed mushrooms and healthy spinach baked in a rich cheesy sauce makes this Keto Chicken Florentine Casserole your new favorite easy dinner!

Keto Chicken Florentine Casserole with piece missing

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❤️ Why You’ll Love This Chicken Florentine Casserole

  • Tender chicken, sautéed mushrooms and healthy spinach
  • Rich and creamy cheese sauce
  • Baked with melted mozzarella cheese on top
  • Loaded with healthy fats
  • Easy to prepare, even make it ahead and bake when you’re ready
Keto Chicken Florentine Casserole being served out of casserole

This is one of my very favorite casseroles to make!  If you need a last minute Low Carb dinner recipe, this Chicken Florentine casserole can be made with ingredients you might already have on hand! 

One of the best things about casseroles, is they are typically very easy to put together and often have a fair amount of servings.  This is great for anyone who struggles with meal prepping and having enough Keto meals on hand.

closeup of Keto Chicken Florentine Casserole with piece missing

When you bake this chicken florentine, your kitchen is going to smell amazing!!  You will find yourself making this one again and again!  It also freezes perfectly, so don’t let your leftovers go to waste!

🛒 Ingredients For Keto Chicken Casserole

  • Cooked Chicken
  • Mushrooms
  • Frozen spinach
  • Heavy cream
  • Mascarpone cheese
  • Parmesan cheese
  • Mozzarella cheese
  • Garlic
  • Butter
  • Salt
  • Pepper

*Exact measurements are listed in the recipe card below.

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🔪 How to Make Chicken Florentine Casserole

Preheat oven to 375°F.

Heat a skillet to medium and add in the butter, then once melted, add in the mushrooms.

raw sliced mushrooms in skillet

Sauté for a few minutes and once they have some good color, add in the garlic.

sauteed mushrooms with minced garlic in skillet

Sauté for about 15 seconds, then add in the mascarpone cheese, turn off the heat and stir until melted. Remove from the heat and allow to cool slightly.

sauteed mushrooms with melted mascarpone cheese in middle of skillet

In a large mixing bowl, add in the chicken, spinach, grated parmesan cheese salt and pepper.

shredded chicken, cooked spinach and grated parmesan cheese in glass bowl unmixed

Add in the heavy cream, half the mozzarella cheese and the mushrooms, garlic and mascarpone mixture.

Keto Chicken Florentine Casserole filling in glass bowl

Stir until well combined, then pour into a 9 x 9 casserole baking dish that’s been sprayed with nonstick spray.

Keto Chicken Florentine Casserole in casserole dish unbaked

Add the remaining mozzarella cheese over the top.

Keto Chicken Florentine Casserole with shredded cheese on top unbaked

Bake for 30 minutes or until the cheese is golden.

overhead view of Keto Chicken Florentine Casserole with chopped parsley on top

💡 Tips for Making Keto Chicken Casserole

  • This can be a great make-ahead dinner, especially for busy weeknights. Simply prepare the ingredients, mix together and add them to the casserole dish. Then store in the fridge, top with the shredded mozzarella cheese and bake when you’re ready.
  • To make your life easier, you can pick up a rotisserie chicken, shred it up and use it in this recipe. It’s definitely a time-saver, verses cooking your own chicken.

☑️ Storage Instructions

Store leftovers in an airtight container in a fridge for a few days or freeze.

🍴 What to Serve with Chicken Florentine

Since this Keto casserole is rich in flavor and healthy fats, a simple side salad would be the most suitable pairing. Greek Salad, Classic Wedge Salad, Mediterranean Cucumber Salad or this Strawberry Spinach Salad are all great options.

Keto Chicken Florentine Casserole with piece missing

🔄 Substitutions and Additions

  • Chicken: As I mentioned above, using store bought rotisserie chicken is a great time saver.
  • Mushrooms: Fresh mushrooms are best and have the most flavor, but in a pinch, you can use jarred/canned mushrooms.
  • Onions or Leeks: For added flavor, you can sauté some yellow onions or leeks along with the mushrooms and add them into the casserole.
  • Cheese: If you’re out of parmesan cheese, Romano or Asiago will work just as well. Provolone or Monterey Jack also makes a great replacement for the mozzarella cheese.
  • Spinach: If you happen to have fresh spinach on hand, you can sauté it in the skillet before adding it to the casserole. Just be sure to make a LOT, we know how spinach shrinks down to almost nothing once cooked!
  • Mascarpone: If you don’t have mascarpone cheese, cream cheese will work as well. Just be sure to adjust your macros accordingly, since cream cheese has slightly more carbs.

What is chicken Florentine made of?

The main components are spinach, chicken of course and a cream sauce. Garlic and a blend of cheeses give it great flavor, while the mushrooms make it hearty, filling and very tasty.

Keto Chicken Florentine Casserole being served out of casserole

How many carbs are in chicken Florentine?

There are only 3 net carbs in each serving of this chicken Florentine casserole.

What kind of chicken can I eat on Keto?

The best thing about chicken on a Keto diet is that all parts, breast, thighs, legs and wings are perfectly suitable!

What is the origin of chicken Florentine?

While one might think it originated in Florence, Italy because of the name, it’s not Italian, it’s actually French.

Why is spinach associated with Florence?

Chicken Florentine originated in 1533 when Catherine de Medici, a Florentine aristocrat, married a French prince and brought her recipes and love for spinach to France, or so the story goes. When you see “Florentine” recipes, they most often contain spinach as a main ingredient.

Keto Chicken Florentine Casserole serving on round white plate with casserole in background

🍽️ More Keto Casseroles

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Keto Chicken Florentine Casserole with piece missing

Keto Chicken Florentine Casserole

Tender chicken, sautéed mushrooms and healthy spinach baked in a rich cheesy sauce makes this Keto Chicken Florentine Casserole your new favorite easy dinner!
5 from 26 votes
Author: Julianne
Servings 8
PREP 5 minutes
COOK 35 minutes
TOTAL 40 minutes

Ingredients
 

  • 14 ounces shredded cooked chicken
  • 8 ounces baby bella mushrooms, sliced
  • 9 ounces frozen spinach, thawed and well drained
  • 1 1/2 cups shredded mozzarella cheese, divided
  • 1 cup heavy cream
  • 1 cup parmesan cheese, grated
  • 1/2 cup mascarpone cheese
  • 2 garlic cloves, minced
  • 2 tablespoons butter
  • 1/2 teaspoon salt
  • 1/4 teaspoon ground black pepper

Instructions
 

  • Preheat oven to 375F. Heat a skillet to medium and add in the butter, then once melted, add in the mushrooms. Sauté for a few minutes and once they have some good color, add in the garlic.
  • Sauté for about 15 seconds, then add in the mascarpone cheese, turn off the heat and stir until melted. Remove from the heat and allow to cool slightly.
  • In a large mixing bowl, add in the chicken, spinach, grated parmesan cheese, salt and pepper. Add in the heavy cream, half the mozzarella cheese and the mushrooms, garlic and mascarpone mixture.
  • Stir until well combined, then pour into a 9 x 9 casserole baking dish that's been sprayed with nonstick spray. Add the remaining mozzarella cheese over the top.
  • Bake for 30 minutes or until the cheese is golden.

*Make sure to scroll up and read the post for substitutions, additions and helpful tips for making this recipe.

Course Main Course
Cuisine Italian
Calories 412kcal
Nutrition Facts
Keto Chicken Florentine Casserole
Amount per Serving
Calories
412
% Daily Value*
Fat
 
33
g
51
%
Saturated Fat
 
21
g
131
%
Carbohydrates
 
4
g
1
%
Fiber
 
1
g
4
%
Sugar
 
2
g
2
%
Protein
 
26
g
52
%
* Percent Daily Values are based on a 2000 calorie diet.

*Nutritional data is provided as a courtesy and is accurate to the best of my knowledge. You can verify it using the nutrition calculator of your choice. All data is based on net carbs, without sugar alcohol: Swerve, Erythritol, Monk Fruit or Allulose.

© Copyright for Keto Cooking Christian LLC. Please use the share buttons to share on social media, but please do not copy/paste the recipe.

Rate this Recipe

*Originally published on August 14, 2018, updated on February 13, 2024 with improvements to the recipe, photos, new recipe information and helpful tips.

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5 from 26 votes (14 ratings without comment)

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Recipe Rating




42 Comments

  1. 5 stars
    This was absolutely wonderful! This is the second time in about a week that I’ve made this dish. I added sautéed onion. I thought this would be runny because of the heavy cream, but it was perfect. Thanks so much for this recipe, and the other million I’ve book marked

    1. I’m so glad you’re loving it! Sautéed onion sounds like a delicious addition. Thanks for trying it (twice!) and for bookmarking so many others. I can’t wait for you to try them.

  2. 5 stars
    I made the Chicken Florentine Casserole this week. It was absolutely delicious and everyone in the house loved it.

  3. 5 stars
    Made this twice using two different subs for the mascarpone – first time was spinach artichoke dip from Costco, second time was cream cheese. Both were excellent! I also play fast and loose with how much and which kinds of cheese but the recipe lends a lot of flexibility there, which is greaf!

    This last time I added half an onion to the pan with my fresh mushrooms and fresh spinach and garlic, just because I had it leftover and it needed to be used lol. We love onion in this house so it worked!

    1. That sounds amazing! I love how you made it your own with different cheeses and that extra onion. That’s a great way to use what you have on hand.

  4. 5 stars
    This was great! I used fresh mushrooms and spinach which I cooked down. I cut a little over a pound of raw chicken breasts into bite sized chunks and followed the rest of the recipe as written. Everyone loved it and there were no leftovers! Served over rice for the non-keto eaters. Definitely will make again!

  5. Could you use a rotisserie chicken.: Besides just being quicker it’s very hard to find chicken during this time. No stores seem to have

  6. 5 stars
    I made this using fresh mushrooms and spinach and also added some halved cherry tomatoes. This has become a “Keto Keeper” in my household! SOOOO tasty!

  7. 5 stars
    So good! I sautéed fresh spinach and mushrooms as suggested in the notes. I even posted to my Instagram @ketolifestylewithjess

    1. That’s wonderful and yes, I saw the pic of your casserole on IG, very nice!! Glad you enjoyed it 🙂

  8. 5 stars
    Can I sub Turkey for the chicken and would I have to adjust the recipe
    Loved it with the chicken but Turkey season is almost here and I love it too

    1. Yes, you absolutely can and I would sub 1:1, so no adjustment would be needed. Great idea, thank you! I might have to try that myself with some leftovers 🙂

  9. 5 stars
    This is definitely a very good recipe . I did have to replace the mascarpone ( I couldn’t get it ) with cottage cheese and it was so delicious.

  10. 5 stars
    This is sooooo yummy! My husband is doing keto but I am not (5 mo pregnant) and this was great for both of us. I took a smaller serving and served it over whole wheat pasta. He enjoyed his over steamed broccoli and cauliflower.

    My modifications; Used a Costco chicken to cut down on prep time. Upped the garlic to three large cloves (we love garlic!). Sautéed a mix of fresh crimini and shiitake mushrooms we had on hand along with a bag of fresh spinach. I also crumbled just a few crunchy pieces of bacon on top for texture for my hubby. Used a cup and half of cream so it was a bit more saucy which we enjoyed.

    Thanks for the great recipe! We will make it again.

    1. Hi Dawn,
      Pasta wouldn’t be Keto or Low Carb. I would recommend something light like a salad.

  11. Can I use fresh mushrooms and fresh spinach instead? Also, would cream cheese work in place of the mascarpone?
    Thank you, Kathy

    1. Hi Kathy, yes to all 3 substitutions, they should all work just fine! With the fresh spinach and mushrooms, I would definitely sauté them before mixing it into the mixing bowl with the other ingredients prior to baking. This will get all the water out so the casserole will hold together and won’t be watery. I hope that helps!

  12. This looks good, however in the picture, the mushrooms that added to the chicken look to be canned. If I use fresh mushrooms, what adjustments do you suggest I make?

    1. Hi Cindy,
      I almost never used canned mushrooms, but I decided to in order to make this a really quick and easy casserole to put together. I can certainly understand wanting to use fresh instead, so I would sauté them before adding them to the mixture. This will get them to release most of their moisture that you can discard, and won’t make the casserole watery. I hope that helps!

  13. 5 stars
    This is my absolute all time favorite casserole recipe! So much flavor and extremely easy to make. I have made 3 times and it is my go-to recipe. I make it on Sunday and it last all week for work. It heats up beautifully and the flavor never leaves! I recommend this to anyone for an easy meal for the family or just portion for lunches. So delectable!!!

    1. Thank you for the wonderful feedback! I’m so glad you like it, I make it all the time too 🙂