This Chicken Alfredo Casserole is packed with tender, juicy chicken, a rich, velvety Alfredo sauce, and plenty of cheesy goodness. Creamy, comforting, and crazy delicious, this is the low-carb dinner the whole family will love.

❤️ Why You’ll Love This Keto Chicken Casserole

• Tender, juicy chicken, savory mushrooms and spinach
• Classic, velvety smooth Alfredo sauce
• Great for meal prep and make-ahead meals
• Easy to make, hearty and filling
• Low carb and gluten-free

If there’s one thing kids and adults alike can’t resist, it’s a cheesy, creamy, baked casserole that makes the whole kitchen smell amazing. This chicken alfredo bake has everything you love. Juicy chicken, an easy homemade Alfredo sauce, and plenty of mozzarella cheese to make every bite rich and gooey. Plus, it’s Keto-friendly, which means you can enjoy all that cheesy goodness without worrying about extra carbs.

This dish is the ultimate comfort food, but it’s also great for meal prep. Make it ahead of time, pop it in the oven when you’re ready, and dinner is served. Whether you’re feeding the family or just need an easy dinner for guests, this alfredo chicken casserole checks all the boxes.

If you love this recipe, you should also try my quick and easy Creamy Shrimp Alfredo recipe.

🛒 Ingredients for Chicken Alfredo Casserole

• Chicken
• Keto Alfredo Sauce
• Mushrooms
• Spinach
• Mozzarella cheese
• Chicken broth
• Olive oil

*Exact measurements are listed in the recipe card below.

🥣 Recommended Tools

• Skillet
• Mixing bowl
• Casserole baking dish

🔪 How to Make Keto Chicken Alfredo Casserole

Preheat oven to 400°F.

Prepare the Keto Alfredo Sauce according to the directions, then set it aside to cool slightly while you prepare the other casserole ingredients.

Add the olive oil and mushrooms to a large skillet.

Sauté until they have some good color, then set them aside to cool slightly.

In a large mixing bowl, add in the mushrooms, chopped chicken, drained spinach and 1 cup of the shredded mozzarella cheese.

Pour in the slightly cooled Alfredo sauce and chicken broth.

Stir until well combined, then pour into a 9 x 9 casserole baking dish that’s been sprayed with olive oil.

Add the remaining shredded mozzarella cheese over the top.

Bake 25 minutes or until the cheese is golden and bubbly.

Allow to cool slightly before serving.  

☑️ Storage Instructions

Fridge: Store in an airtight container for up to 3-4 days.

Freezer: Wrap tightly and freeze for up to 2 months. Thaw overnight in the fridge before reheating.

🍴 What to Serve with This Creamy Casserole

This is a complete meal in one, but you can serve it with some tasty Italian Breadsticks or a fresh, crisp green Caesar salad with homemade Caesar Dressing.

💡 Tips

• Drain the spinach well. Squeeze out as much liquid as possible to avoid a watery casserole.

• Don’t skip the mascarpone in the sauce. It makes it extra creamy and balances the sharpness of the parmesan.

• Bake uncovered. This helps the top layer of mozzarella cheese get that golden, bubbly finish.

• Let it rest before serving. The casserole will thicken up slightly as it cools, making it easier to scoop.

🔄 Substitutions and Additions

• Add cauliflower: Chopped cauliflower makes a great filler if you want more veggies.
• Swap spinach for broccoli: Broccoli adds a classic twist that works beautifully.
• Use rotisserie chicken: A huge time-saver and just as tasty.
• Try different cheeses: A little gouda or provolone adds an interesting depth of flavor.
• Extra garlicky: Roast a few cloves and mash them into the sauce.
• Crispy bacon: Top it with crispy bacon…because everything is better with bacon.
• Crunchy topping. Crushed pork rinds can mimic breadcrumbs for a crispy top layer.

Is Alfredo Keto?

It certainly is. Well, homemade alfredo sauce is. It is mostly cream and cheese. That is what I consider the PERFECT Keto sauce.

Can I Freeze Chicken Alfredo Casserole?

Absolutely! This casserole freezes very well. It should be noted than sometimes the dairy in casseroles will try to separate some. If that happens to you with this keto chicken casserole, give it a gentle stir to reincorporate the sauce and it will be just fine.

In order to keep the casserole as fresh as possible while in the freezer, you will want to freeze it in an airtight container. If there is a lot of space between the top of the casserole and the lid, place a piece of plastic wrap directly on top of the casserole.

It will keep for up to several months.

What Are Some Other Ways to Serve Keto Alfredo Sauce?

Once you taste the flavors of this low carb sauce, you may want to try some of these delicious ways to serve it.

I love it over grilled shrimp and served along with Palmini Noodles or zucchini Alfredo sauce makes a great dipping sauce for these Keto Italian Breadsticks. Drizzle low carb alfredo sauce over Keto Fried Chicken Tenders for a little bit of decadence.

The possibilities for this sauce is truly endless. You can serve it over any grilled veggies, like eggplant, zucchini or asparagus and it will take low carb veggies to a whole new level.

My Casserole Came Out Watery! What Went Wrong?

Make sure to drain the spinach well and avoid adding extra liquid beyond what the recipe calls for.

🍽️ More Keto Casseroles

• Spinach Artichoke Casserole
• Chicken Parmesan Casserole
• Easy Taco Casserole
• Chicken Pot Pie Casserole
• Loaded Creamy Cauliflower Casserole
• Chicken Cordon Bleu Casserole
• Easy Sausage & Pepper Casserole
• Bacon Cheeseburger Casserole
• Chicken Florentine Casserole

*Originally published on December 29, 2018, updated on April 25, 2025 with improvements to the recipe, new photos, new recipe information and helpful tips.