This delicious low carb Italian Spaghetti Squash Casserole is the ultimate comfort food, filled with flavorful homemade marinara, tender spaghetti squash and gooey cheese.

❤️ Why You’ll Love this Spaghetti Squash Casserole

• Satisfy your cravings for spaghetti
• Flavorful Italian marinara with chunks of sausage and beef
• Tender strands of squash makes a great low carb pasta alternative
• Gooey cheesy topping
• Perfect make-ahead dinner

Tender roasted spaghetti squash serves as a low carb pasta substitute in this Italian casserole, but you won’t miss it one bit! In fact, the roasted squash adds the perfect hint of caramelized sweetness that works beautifully with the savory meat sauce.

If you’re looking for a healthy and hearty, Keto-friendly casserole the entire family will love, this spaghetti squash casserole is the perfect answer. And the best part, leftovers are even better the next day, making it ideal for meal prep!

This casserole has everything it needs to make it an ideal meal-in-one that’s healthy and nutritious. I love to serve it with these light and fluffy Keto Garlic Rolls or some of this Keto Braided Herb Bread.

If you love spaghetti squash, you should also check out this amazing Parmesan Garlic Roasted Spaghetti recipe. It’s a delicious Keto side dish that goes well with everything from Italian Meatballs to Air Fryer Chicken Tenders.

🛒 What’s in Spaghetti Squash Casserole

• Spaghetti squash
• Keto Italian Meat Sauce
• Mozzarella cheese

*Exact measurements are listed in the recipe card below.

🥣 Recommended Tools

• Baking sheet
• Mixing bowl
• 9 x 13 Casserole baking dish

🔪 How to Make Italian Spaghetti Squash

Preheat oven to 400°F.

Prepare to roast your spaghetti squash in the oven for 35 minutes using this method.

Tip: Roasting the spaghetti squash gives it extra flavor, but if you’re in a hurry, you can use the “cook in the microwave” method instead.

Once you add the spaghetti squash in the oven, you can start your sauce.

Prepare a batch of this easy Keto Italian Meat Sauce, which should be ready around the same time the spaghetti squash comes out of the oven and has cooled enough to handle.

Tip: If you don’t have time to make your own meat sauce and have a low carb version on hand, I do still recommend adding browned ground beef and Italian sausage to it.

Using a fork, separate the spaghetti like strands and add them to a large mixing bowl.

Pour 2/3 of the Italian meat sauce over the top and mix to combine, making sure the squash is well coated in the sauce.

Pour the mixture into a 9×13 casserole baking dish that’s been sprayed with nonstick spray.

Top with the remaining meat sauce and mozzarella cheese.

Bake for 15-20 minutes or until the cheese has melted and is slightly golden.

This also makes a great “make-ahead” meal, so if you roast the spaghetti squash and make the Italian meat sauce ahead of time, you can assemble and bake when you’re ready.

Is Spaghetti Squash Good for a Keto Diet?

Spaghetti squash is often used as a Keto friendly substitute for pasta. Not only is it low in carbs, but it’s also a good source of fiber, vitamins and minerals, like C, Manganese, and B6. It also contains small amounts of magnesium, thiamine, folate, iron, and calcium.

Why is My Squash Casserole Watery?

Spaghetti squash, like most vegetables contain a lot of water. That’s why it’s important to salt the spaghetti squash before roasting it to help draw out the excess moisture.

Once you have roasted it and separated the strands, you can also blot the squash with paper towels or allow it to sit in a colander for few minutes.

How to Bake Spaghetti Squash Keto?

Baking or roasting spaghetti squash is easier than it seems. For easy step-by-step instructions check out this article.

Can You Have Italian Food on Keto?

Of course, you can. Italian food reaches far beyond pasta, though admittedly, pasta is very common in Italian recipes. If you’re looking for some other classic Italian recipes with a Keto makeover, check out these top favorites:

• Chicken Marsala
• Creamy Tuscan Chicken
• Italian Breadsticks
• Italian Beef Braciole
• Chicken Parmesan

Is Spaghetti Sauce Keto?

Store-bought spaghetti sauce (or marinara) usually contains a fair amount of added sugar. So, the best way to ensure you’re getting a low carb marinara sauce with clean and quality ingredients is to make it homemade.

The easy Italian meat sauce used in this casserole is unbelievably quick and simple to make. The flavors are so rich and robust that you’ll want to double or triple the batch, freeze the leftovers so you’ll always have some on hand.

Can I Make This Casserole without Meat?

If you’re wanting to make this casserole for Meatless Monday or maybe you’re looking for a hearty side dish, you can substitute the meat sauce for this simple, Homemade Keto Marinara.

More Keto Casserole Recipes

• Spinach Artichoke Casserole
• Chicken Parmesan Casserole
• Easy Taco Casserole
• Chicken Pot Pie Casserole
• Loaded Creamy Cauliflower Casserole
• Chicken Cordon Bleu Casserole
• Easy Sausage & Pepper Casserole
• Bacon Cheeseburger Casserole
• Chicken Florentine Casserole